Claim files are sent from DrChrono 7 days a week, 365 days per year, regardless of weekends and/or holidays. The time they are sent depends on what clearinghouse they are being submitted to.
Currently (as of November 2022) claims are submitted as follows:
Carisk Partners - 5pm EST daily
Change Healthcare - 6pm EST daily
TriZetto - 10am and 6pm daily